Structural studies on novel antitubercular targets

Studies on Thiazolyliminothiazoline Derivatives as Potential Antitubercular Agents

In this study, eight new ethyl {2-[3,4-diaryl-3H-thiazol-2ylidenamino]thiazol-4-yl}acetate were synthesized by reacting ethyl [2-(3-aryl(thiouredio)thiazol-4-yl]acetate and phenacyl bromides in ethanol. The solid was filtered and recrystallized from ethanol. The chemical structures of the synthesized compounds were proven by elemental analysis, IR, 1H-NMR and MS spectral data. The compounds wer...

Studies on the Antitubercular Compounds (XII) Effect on Antitubercular Activity of Acid Hydrazide by the Condensation with Aldehyde Shichiro

Design and Synthesis of Some Novel Fluorobenzimidazoles Substituted with Structural Motifs Present in Physiologically Active Natural Products for Antitubercular Activity

Keeping in view the drawbacks associated with research on anti-TB drugs based on plant extracts and the non-availability of fluorinated natural products with antitubercular activity has prompted us to make an effort towards the synthesis and characterization of a novel series of fifteen substituted fluorobenzimidazoles. The newly synthesized compounds were characterized by I.R, 1H-NMR, 13C-NMR,...

Design and Synthesis of Some Novel Fluorobenzimidazoles Substituted with Structural Motifs Present in Physiologically Active Natural Products for Antitubercular Activity

Keeping in view the drawbacks associated with research on anti-TB drugs based on plant extracts and the non-availability of fluorinated natural products with antitubercular activity has prompted us to make an effort towards the synthesis and characterization of a novel series of fifteen substituted fluorobenzimidazoles. The newly synthesized compounds were characterized by I.R, 1H-NMR, 13C-NMR,...

Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies

In continuation of our endeavor towards the design and development of potent and effective antimicrobial agents, three series of phthalimide derivatives (4a-i, 5a-f, and 6a-c) were synthesized, fully characterized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. These efforts led to the discovery of nine compounds 4c, 4f, 4g, 4h, 4i, 5c, 5d, 5e, and ...